Integrin alpha4beta1

Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.

Also Known As:

VLA-4; CD49d-CD29; Integrin Heterodimer alpha4beta1; Integrin alpha(4)beta(1); Very Late Activation Antigen-4; Very Late Antigen-4; alpha4beta1 Integrin; Antigen-4, Very Late; Heterodimer alpha4beta1, Integrin; Integrin, alpha4beta1; Late Antigen-4, Very; Very Late Activation Antigen 4; Very Late Antigen 4; alpha4beta1, Integrin; alpha4beta1, Integrin Heterodimer

Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - Cell Adhesion Molecules: 4858
        Lymphocyte Homing Receptors: 25
        Integrin alpha4beta1: 564
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - Cell Adhesion Molecules: 4858
        Lymphocyte Homing Receptors: 25
        Integrin alpha4beta1: 564
  - Membrane Proteins: 10078
    - Membrane Glycoproteins: 2252
      - Cell Adhesion Molecules: 4858
        Lymphocyte Homing Receptors: 25
        Integrin alpha4beta1: 564
    - Cell Surface Receptors: 2125
      - Immunologic Receptors: 9
        Integrins: 14304
        Fibronectin Receptors: 37
        Integrin alpha4beta1: 564
        Very Late Antigen Receptors: 8
        Integrin alpha4beta1: 564
        Lymphocyte Homing Receptors: 25
        Integrin alpha4beta1: 564
Biological Factors: 2472
- Antigens: 143924
  - Surface Antigens: 5813
    - Cell Adhesion Molecules: 4858
      - Lymphocyte Homing Receptors: 25
        Integrin alpha4beta1: 564

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E Jüngel Research Topics

Disease

Drug/Important Bio-Agent (IBA)